APOBEC3F

DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.^[3][4][5]

APOBEC3F
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3WUS, 4IOU, 4J4J, 5HX5, 5HX4
Identifiers
Aliases	APOBEC3F, A3F, ARP8, BK150C2.4.MRNA, KA6, apolipoprotein B mRNA editing enzyme catalytic subunit 3F
External IDs	OMIM: 608993; HomoloGene: 105867; GeneCards: APOBEC3F; OMA:APOBEC3F - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,040,604 bp[1] End 39,055,972 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte spleen right ovary left ovary right uterine tube lymph node right adrenal gland left adrenal cortex right adrenal cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function cytidine deaminase activity zinc ion binding metal ion binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines protein binding catalytic activity RNA binding hydrolase activity identical protein binding Cellular component cytoplasm P-body apolipoprotein B mRNA editing enzyme complex nucleus ribonucleoprotein complex Biological process negative regulation of transposition negative regulation of viral process immune system process base conversion or substitution editing negative regulation of viral genome replication defense response to virus DNA cytosine deamination DNA demethylation innate immune response negative regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of defense response to virus by host cytidine deamination cytidine to uridine editing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200316 n/a Ensembl ENSG00000128394 n/a UniProt Q8IUX4 n/a RefSeq (mRNA) NM_001006666 NM_145298 n/a RefSeq (protein) NP_001006667 NP_660341 n/a Location (UCSC) Chr 22: 39.04 – 39.06 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]