ARF1

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.^[5]

ARF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HUR, 1RE0, 1U81, 3O47, 4HMY, 1R8Q, 1RRG, 1RRF
Identifiers
Aliases	ARF1, ADP ribosylation factor 1, PVNH8
External IDs	OMIM: 103180; MGI: 99431; HomoloGene: 133930; GeneCards: ARF1; OMA:ARF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 228,082,660 bp[1] End 228,099,212 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 59,102,238 bp[2] End 59,119,096 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum stromal cell of endometrium cardiac muscle tissue of right atrium beta cell pituitary gland anterior pituitary corpus epididymis right lung upper lobe of lung upper lobe of left lung Top expressed in zygote dentate gyrus of hippocampal formation granule cell yolk sac ankle joint tail of embryo right kidney primary visual cortex granulocyte superior frontal gyrus lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase D activator activity nucleotide binding GTP binding magnesium ion binding GTPase activity GDP binding protein binding RNA binding protein domain specific binding protein heterodimerization activity Cellular component extracellular exosome late endosome cytoplasm synapse trans-Golgi network Golgi apparatus cell junction endomembrane system peroxisomal membrane cell leading edge neuron projection postsynaptic density postsynaptic membrane membrane focal adhesion intracellular anatomical structure perinuclear region of cytoplasm sarcomere COPI-coated vesicle cytosol Golgi membrane plasma membrane protein-containing complex glutamatergic synapse Biological process positive regulation of endocytosis positive regulation of protein secretion very-low-density lipoprotein particle assembly mitigation of host defenses by virus positive regulation of calcium ion-dependent exocytosis regulation of receptor internalization synaptic vesicle budding small GTPase mediated signal transduction cellular copper ion homeostasis long-term depression antigen processing and presentation of exogenous peptide antigen via MHC class II Golgi to transport vesicle transport post-Golgi vesicle-mediated transport actin filament organization lysosomal membrane organization positive regulation of ER to Golgi vesicle-mediated transport dendritic spine organization regulation of phospholipid metabolic process regulation of Arp2/3 complex-mediated actin nucleation positive regulation of late endosome to lysosome transport protein transport phosphatidylinositol biosynthetic process positive regulation of sodium ion transmembrane transport vesicle-mediated transport positive regulation of catalytic activity positive regulation of dendritic spine development mitotic cleavage furrow ingression interleukin-12-mediated signaling pathway transport intracellular protein transport Golgi to plasma membrane transport postsynaptic actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 375 11840 Ensembl ENSG00000143761 ENSMUSG00000048076 UniProt P84077 P84078 RefSeq (mRNA) NM_001658 NM_001024226 NM_001024227 NM_001024228 NM_001130408 NM_007476 RefSeq (protein) NP_001019397 NP_001019398 NP_001019399 NP_001649 NP_001123880 NP_031502 Location (UCSC) Chr 1: 228.08 – 228.1 Mb Chr 11: 59.1 – 59.12 Mb PubMed search [3] [4]
Wikidata
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Function

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[6]

The major mechanism of action of Brefeldin A is through inhibition of ARF1.

Interactions

ARF1 has been shown to interact with:

• CHRM3,^[7]
• COPB1,^[8][9]
• GGA3,^[10][11] and
• PLD2.^[12][13]