GGA3

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.^[5][6]

GGA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JPL, 1JUQ, 1LF8, 1P4U, 1WR6, 1YD8
Identifiers
Aliases	GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
External IDs	OMIM: 606006; MGI: 2384159; HomoloGene: 121703; GeneCards: GGA3; OMA:GGA3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,236,599 bp[1] End 75,262,363 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,475,081 bp[2] End 115,494,877 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte pylorus gastric mucosa spleen monocyte nipple lymph node upper lobe of left lung fundus Top expressed in zygote secondary oocyte neural layer of retina tail of embryo primary visual cortex superior frontal gyrus cerebellar cortex yolk sac facial motor nucleus genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin binding Cellular component endosome trans-Golgi network endosome membrane intracellular anatomical structure membrane clathrin adaptor complex Golgi apparatus early endosome membrane recycling endosome membrane early endosome recycling endosome Biological process protein transport intracellular protein transport positive regulation of protein catabolic process vesicle-mediated transport protein localization to lysosome regulation of protein stability protein destabilization endocytic recycling protein localization to cell surface Golgi to plasma membrane protein transport negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23163 260302 Ensembl ENSG00000125447 ENSMUSG00000020740 UniProt Q9NZ52 Q8BMI3 RefSeq (mRNA) NM_001172703 NM_001172704 NM_001291641 NM_001291642 NM_014001 NM_138619 NM_001252067 NM_173048 RefSeq (protein) NP_001166174 NP_001166175 NP_001278570 NP_001278571 NP_054720 NP_619525 NP_001238996 NP_766636 Location (UCSC) Chr 17: 75.24 – 75.26 Mb Chr 11: 115.48 – 115.49 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.^[7]

Interactions

GGA3 has been shown to interact with ARF1^[5][8] and ARF3.^[6][9]