ARF5

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.^[5][6]

ARF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6H
Identifiers
Aliases	ARF5, ADP ribosylation factor 5
External IDs	OMIM: 103188; MGI: 99434; HomoloGene: 129625; GeneCards: ARF5; OMA:ARF5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 127,588,386 bp[1] End 127,591,700 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 28,423,559 bp[2] End 28,426,601 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 skin of leg right frontal lobe skin of abdomen body of pancreas right hemisphere of cerebellum primary visual cortex superior frontal gyrus granulocyte Top expressed in lip dentate gyrus of hippocampal formation granule cell granulocyte primary visual cortex superior frontal gyrus ventricular zone perirhinal cortex right kidney yolk sac entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity Cellular component cytoplasm perinuclear region of cytoplasm plasma membrane Golgi apparatus extracellular exosome intracellular anatomical structure membrane Biological process protein transport small GTPase mediated signal transduction vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum transport intracellular protein transport Golgi to plasma membrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 381 11844 Ensembl ENSG00000004059 ENSMUSG00000020440 UniProt P84085 P84084 RefSeq (mRNA) NM_001662 NM_007480 RefSeq (protein) NP_001653 NP_031506 Location (UCSC) Chr 7: 127.59 – 127.59 Mb Chr 6: 28.42 – 28.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor 5 (ARF5) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene spans approximately 3.2kb of genomic DNA and contains six exons and five introns.^[6]

Interactions

ARF5 has been shown to interact with ARFIP2.^[7][8]