ARFIP2

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.^[5][6][7]

ARFIP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I49, 1I4D, 1I4L, 1I4T, 4DCN
Identifiers
Aliases	ARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDs	OMIM: 601638; MGI: 1924182; HomoloGene: 8234; GeneCards: ARFIP2; OMA:ARFIP2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,474,683 bp[1] End 6,481,479 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,283,410 bp[2] End 105,289,623 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa beta cell body of pancreas anterior pituitary body of stomach right uterine tube trachea rectum minor salivary glands right lobe of thyroid gland Top expressed in dentate gyrus of hippocampal formation granule cell neural layer of retina lacrimal gland superior frontal gyrus pyloric antrum genital tubercle parotid gland ventricular zone tail of embryo cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4-phosphate binding protein domain specific binding protein binding GTP binding identical protein binding cadherin binding GTP-dependent protein binding phospholipid binding Cellular component cell cortex trans-Golgi network membrane plasma membrane ruffle cytosol cytoplasm Biological process ruffle organization small GTPase mediated signal transduction actin cytoskeleton organization regulation of Arp2/3 complex-mediated actin nucleation lamellipodium assembly intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23647 76932 Ensembl ENSG00000132254 ENSMUSG00000030881 UniProt P53365 Q8K221 RefSeq (mRNA) NM_001242854 NM_001242855 NM_001242856 NM_012402 NM_029802 RefSeq (protein) NP_001229783 NP_001229784 NP_001229785 NP_036534 NP_001357335 NP_001357337 NP_001357338 NP_001357340 NP_001357341 NP_001357342 NP_001363487 NP_001363488 NP_001363489 NP_001363490 NP_001363491 NP_001363492 NP_001363493 NP_084078 Location (UCSC) Chr 11: 6.47 – 6.48 Mb Chr 7: 105.28 – 105.29 Mb PubMed search [3] [4]
Wikidata
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Interactions

ARFIP2 has been shown to interact with Arf6,^[8][9] ARF3,^[6] ARF5^[6][9] and RAC1.^[5][9][10]