ARHGAP1

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.^[5][6]

ARHGAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Identifiers
Aliases	ARHGAP1, CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP, Rho GTPase activating protein 1
External IDs	OMIM: 602732; MGI: 2445003; HomoloGene: 20909; GeneCards: ARHGAP1; OMA:ARHGAP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 46,677,080 bp[1] End 46,700,619 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 91,480,205 bp[2] End 91,502,671 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium saphenous vein epithelium of esophagus parietal pleura visceral pleura amniotic fluid urethra decidua tail of epididymis vena cava Top expressed in yolk sac granulocyte corneal stroma lip genital tubercle tail of embryo morula morula blastocyst dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein binding GTPase activator activity cadherin binding Cellular component cytosol extracellular exosome cytoplasm endosome membrane perinuclear region of cytoplasm sorting endosome membrane integral component of membrane Biological process regulation of small GTPase mediated signal transduction Rho protein signal transduction signal transduction positive regulation of GTPase activity small GTPase mediated signal transduction positive regulation of signal transduction transferrin transport iron ion import across cell outer membrane negative regulation of endocytic recycling endosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 392 228359 Ensembl ENSG00000175220 ENSMUSG00000027247 UniProt Q07960 Q5FWK3 RefSeq (mRNA) NM_004308 NM_001145902 NM_146124 NM_001359970 RefSeq (protein) NP_004299 NP_001139374 NP_666236 NP_001346899 Location (UCSC) Chr 11: 46.68 – 46.7 Mb Chr 2: 91.48 – 91.5 Mb PubMed search [3] [4]
Wikidata
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Interactions

ARHGAP1 has been shown to interact with:

• BNIP2^[7][8]
• CDC42,^{[7][9][10][11]} and
• RHOA.^{[10][11][12][13]}