BNIP2

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.^[5][6]

BNIP2
Identifiers
Aliases	BNIP2, BNIP-2, NIP2, BCL2/adenovirus E1B 19kDa interacting protein 2, BCL2 interacting protein 2
External IDs	OMIM: 603292; MGI: 109327; HomoloGene: 3194; GeneCards: BNIP2; OMA:BNIP2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.2 Start 59,659,146 bp[1] End 59,689,534 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 69,896,748 bp[2] End 69,915,599 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon monocyte epithelium of colon bone marrow cells rectum body of pancreas minor salivary glands right uterine tube right lung gallbladder Top expressed in ascending aorta aortic valve tunica media of zone of aorta genital tubercle tail of embryo iris ciliary body stroma of bone marrow fossa body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity calcium ion binding identical protein binding protein binding exopolyphosphatase activity Cellular component perinuclear region of cytoplasm cytoplasm intracellular membrane-bounded organelle nuclear envelope cytosol membrane integral component of membrane Biological process positive regulation of muscle cell differentiation negative regulation of apoptotic process apoptotic process positive regulation of GTPase activity polyphosphate catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 663 12175 Ensembl ENSG00000140299 ENSMUSG00000011958 UniProt Q12982 O54940 RefSeq (mRNA) NM_004330 NM_001320674 NM_001320675 NM_001008238 NM_016787 NM_001374750 RefSeq (protein) NP_001307603 NP_001307604 NP_004321 NP_001354986 NP_001354987 NP_001354988 NP_001354989 NP_001354990 NP_001008239 NP_058067 NP_001361679 Location (UCSC) Chr 15: 59.66 – 59.69 Mb Chr 9: 69.9 – 69.92 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL-2, also an apoptotic protector.^[6]

Interactions

BNIP2 has been shown to interact with:

• ARHGAP1,^[7][8]
• Bcl-2,^[5][9] and
• CDC42.^[7][8][10]