ARL1

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.^[5]

ARL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UPT, 4DCN, 5EE5
Identifiers
Aliases	ARL1, ARFL1, ADP ribosylation factor like GTPase 1
External IDs	OMIM: 603425; MGI: 99436; HomoloGene: 20319; GeneCards: ARL1; OMA:ARL1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.2 Start 101,393,116 bp[1] End 101,407,772 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 88,566,720 bp[2] End 88,579,956 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans stromal cell of endometrium endothelial cell Achilles tendon Brodmann area 23 Pons saphenous vein rectum epithelium of colon superior surface of tongue Top expressed in ileum quadriceps femoris muscle jejunum proximal tubule uterus pancreas muscle of thigh stomach ovary duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding enzyme activator activity GTPase activity protein domain specific binding metal ion binding GTP binding Cellular component Golgi apparatus Golgi membrane intracellular anatomical structure membrane cytoplasm trans-Golgi network trans-Golgi network membrane cytosol Biological process protein localization to Golgi apparatus toxin metabolic process activation of phospholipase D activity retrograde transport, endosome to Golgi Golgi organization Golgi vesicle transport intracellular protein transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 400 104303 Ensembl ENSG00000120805 ENSMUSG00000060904 UniProt P40616 P61211 RefSeq (mRNA) NM_001301068 NM_001177 NM_025859 RefSeq (protein) NP_001168 NP_001287997 NP_080135 Location (UCSC) Chr 12: 101.39 – 101.41 Mb Chr 10: 88.57 – 88.58 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.^[5]

Interactions

ARL1 has been shown to interact with GOLGA4^[6][7] and GOLGA1.^[6]