GOLGA4

Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.^[5][6]

GOLGA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R4A, 1UPT
Identifiers
Aliases	GOLGA4, CRPF46, GCP2, GOLG, MU-RMS-40.18, golgin A4, Trans-GolgiI p230, Golgin 245, p230
External IDs	OMIM: 602509; MGI: 1859646; HomoloGene: 68224; GeneCards: GOLGA4; OMA:GOLGA4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 37,243,191 bp[1] End 37,366,879 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 118,506,267 bp[2] End 118,582,519 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes jejunal mucosa biceps brachii Skeletal muscle tissue of rectus abdominis thoracic diaphragm right ventricle Skeletal muscle tissue of biceps brachii myocardium of left ventricle cartilage tissue triceps brachii muscle Top expressed in muscle of thigh digastric muscle Paneth cell triceps brachii muscle soleus muscle vastus lateralis muscle plantaris muscle temporal muscle Rostral migratory stream tibialis anterior muscle More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase binding protein binding Cellular component cytoplasm Golgi membrane trans-Golgi network Golgi apparatus extracellular exosome intracellular membrane-bounded organelle membrane cytosol Biological process positive regulation of axon extension vesicle-mediated transport Golgi to plasma membrane protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2803 54214 Ensembl ENSG00000144674 ENSMUSG00000038708 UniProt Q13439 Q49A56 Q91VW5 RefSeq (mRNA) NM_001172713 NM_002078 NM_018748 RefSeq (protein) NP_001166184 NP_002069 NP_001166184.1 NP_002069.2 NP_061218 Location (UCSC) Chr 3: 37.24 – 37.37 Mb Chr 9: 118.51 – 118.58 Mb PubMed search [3] [4]
Wikidata
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The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternative splice variants have been described but their full-length nature has not been determined.^[6]

Interactions

GOLGA4 has been shown to interact with ARL1.^[7][8]