ATF5

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.^[5]

ATF5
Identifiers
Aliases	ATF5, ATFX, HMFN0395, activating transcription factor 5
External IDs	OMIM: 606398; MGI: 2141857; HomoloGene: 32142; GeneCards: ATF5; OMA:ATF5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,928,702 bp[1] End 49,933,935 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,461,680 bp[2] End 44,466,082 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right adrenal cortex gastric mucosa left adrenal gland left adrenal cortex left testis vena cava right testis monocyte appendix Top expressed in olfactory system olfactory epithelium left lobe of liver lip esophagus molar calvaria ankle plantaris muscle extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding tubulin binding kinase binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component centrosome transcription regulator complex nucleoplasm microtubule organizing center cytoskeleton nucleus cytoplasm cytosol Biological process negative regulation of cell cycle G2/M phase transition regulation of transcription, DNA-templated olfactory bulb interneuron differentiation multicellular organism growth regulation of transcription by RNA polymerase II negative regulation of apoptotic process post-embryonic development transcription, DNA-templated cerebellar granule cell precursor proliferation positive regulation of transcription, DNA-templated regulation of centrosome cycle circadian rhythm olfactory bulb interneuron development regulation of gene expression olfactory lobe development negative regulation of transcription, DNA-templated fat cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22809 107503 Ensembl ENSG00000169136 ENSMUSG00000038539 UniProt Q9Y2D1 O70191 RefSeq (mRNA) NM_001193646 NM_001290746 NM_012068 NM_030693 RefSeq (protein) NP_001180575 NP_001277675 NP_036200 NP_109618 Location (UCSC) Chr 19: 49.93 – 49.93 Mb Chr 7: 44.46 – 44.47 Mb PubMed search [3] [4]
Wikidata
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Function

First described by Nishizawa and Nagata,^[6] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.^[7][8]

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

See also

• Activating transcription factor

Interactions

ATF5 has been shown to interact with DISC1^[9] and TRIB3.^[10]