Top Qs
Timeline
Chat
Perspective

TRIB3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

TRIB3
Remove ads

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.[5][6][7]

Quick Facts Identifiers, Aliases ...
Remove ads
Remove ads

Function

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1.[7] TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target.[8][9]

Remove ads

Interactions

TRIB3 has been shown to interact with:

References

Further reading

Loading content...
Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads