TRIB3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

TRIB3

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.[5][6][7]

Quick Facts Identifiers, Aliases ...
TRIB3
Identifiers
AliasesTRIB3, C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3
External IDsOMIM: 607898; MGI: 1345675; HomoloGene: 10902; GeneCards: TRIB3; OMA:TRIB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144554
NM_175093

RefSeq (protein)

NP_780302

Location (UCSC)Chr 20: 0.36 – 0.4 MbChr 2: 152.18 – 152.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1.[7] TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target.[8][9]

Interactions

TRIB3 has been shown to interact with:

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.