ATG4B

Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene.^[4]

ATG4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CY7, 2D1I, 2Z0D, 2Z0E, 2ZZP
Identifiers
Aliases	ATG4B, APG4B, AUTL1, autophagy related 4B cysteine peptidase, HsAPG4B
External IDs	OMIM: 611338; MGI: 1913865; HomoloGene: 100868; GeneCards: ATG4B; OMA:ATG4B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,637,213 bp[1] End 241,673,857 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary right lobe of thyroid gland left testis left lobe of thyroid gland body of uterus canal of the cervix right ovary left ovary mucosa of transverse colon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity endopeptidase activity protein binding hydrolase activity cysteine-type endopeptidase activity Cellular component cytoplasm cytosol Biological process autophagy protein transport autophagy of nucleus C-terminal protein lipidation positive regulation of protein catabolic process autophagy of mitochondrion autophagosome assembly macroautophagy proteolysis protein targeting to membrane protein delipidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23192 66615 Ensembl ENSG00000168397 n/a UniProt Q9Y4P1 Q8BGE6 RefSeq (mRNA) NM_013325 NM_178326 NM_174874 NM_001368266 RefSeq (protein) NP_037457 NP_847896 NP_777363 NP_001355195 Location (UCSC) Chr 2: 241.64 – 241.67 Mb n/a PubMed search [2] [3]
Wikidata
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Function

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[4] One main function of Atg4 is to cleave the pre-protein of Atg8, leading to the non-lipidated soluble (-I) form which can be processed further by Atg3, Atg7, Atg5-12 into the lipidated form (-II) anchored to the autophagic membrane.

Interactions

ATG4B has been shown to interact with GABARAPL2.^[5][6]