GABARAPL2

Gamma-aminobutyric acid receptor-associated protein-like 2 is a protein that in humans is encoded by the GABARAPL2 gene.^[5][6]

GABARAPL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CO7
Identifiers
Aliases	GABARAPL2, ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2, GABA type A receptor associated protein like 2
External IDs	OMIM: 607452; MGI: 1890602; HomoloGene: 68550; GeneCards: GABARAPL2; OMA:GABARAPL2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.1 Start 75,566,375 bp[1] End 75,577,881 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 112,667,335 bp[2] End 112,680,244 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons Brodmann area 46 cerebellar vermis internal globus pallidus superior vestibular nucleus hypothalamus subthalamic nucleus spinal cord C1 segment nucleus accumbens Top expressed in hypothalamus neural tube cerebellar cortex ganglionic eminence blastocyst morula dentate gyrus of hippocampal formation granule cell right kidney Cortex of frontal lobe bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GABA receptor binding microtubule binding ATPase binding protein binding beta-tubulin binding SNARE binding ubiquitin protein ligase binding Cellular component cytoplasm Golgi apparatus Golgi membrane intracellular anatomical structure autophagosome autophagosome membrane cytoplasmic vesicle cytosol Biological process positive regulation of ATP-dependent activity autophagy protein transport negative regulation of proteasomal protein catabolic process intra-Golgi vesicle-mediated transport macroautophagy autophagosome maturation autophagosome assembly autophagy of mitochondrion cellular response to nitrogen starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11345 93739 Ensembl ENSG00000034713 ENSMUSG00000031950 UniProt P60520 P60521 RefSeq (mRNA) NM_007285 NM_026693 RefSeq (protein) NP_009216 NP_080969 Location (UCSC) Chr 16: 75.57 – 75.58 Mb Chr 8: 112.67 – 112.68 Mb PubMed search [3] [4]
Wikidata
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Interactions

GABARAPL2 has been shown to interact with ULK1,^[7] ATG4B,^[8][9] and FAM134B.^[10]