Protein AATF

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.^[5][6][7]

AATF
Identifiers
Aliases	AATF, BFR2, CHE-1, CHE1, DED, Apoptosis-antagonizing transcription factor, apoptosis antagonizing transcription factor
External IDs	OMIM: 608463; MGI: 1929608; HomoloGene: 40811; GeneCards: AATF; OMA:AATF - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 36,948,925 bp[1] End 37,056,871 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 84,422,855 bp[2] End 84,513,522 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte corpus callosum Achilles tendon tibial arteries blood skin of leg bone marrow body of pancreas sural nerve Top expressed in morula epiblast embryo tail of embryo genital tubercle primary oocyte yolk sac endothelial cell of lymphatic vessel spermatocyte embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein domain specific binding DNA-binding transcription factor activity leucine zipper domain binding protein binding tau protein binding RNA binding protein kinase binding Cellular component cytoplasm Golgi apparatus nucleus nucleolus Biological process embryonic cleavage ribosome biogenesis negative regulation of apoptotic process cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated cell adhesion negative regulation of amyloid precursor protein biosynthetic process regulation of mitotic cell cycle negative regulation of superoxide anion generation negative regulation of reactive oxygen species metabolic process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26574 56321 Ensembl ENSG00000275700 ENSG00000276072 ENSMUSG00000018697 UniProt Q9NY61 Q9JKX4 RefSeq (mRNA) NM_012138 NM_019816 RefSeq (protein) NP_036270 NP_062790 Location (UCSC) Chr 17: 36.95 – 37.06 Mb Chr 11: 84.42 – 84.51 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.^[7]

Interactions

Protein AATF has been shown to interact with:

• PAWR,^[8]
• POLR2J,^[6]
• Retinoblastoma protein,^[6][9] and
• Transcription factor Sp1.^[10]