BAT2

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.^[5][6][7]

PRRC2A
Identifiers
Aliases	PRRC2A, BAT2, D6S51, D6S51E, G2, proline rich coiled-coil 2A
External IDs	OMIM: 142580; MGI: 1915467; HomoloGene: 10567; GeneCards: PRRC2A; OMA:PRRC2A - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,620,715 bp[1] End 31,637,771 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.59 cM Start 35,368,052 bp[2] End 35,383,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis ventricular zone pituitary gland anterior pituitary right hemisphere of cerebellum right frontal lobe ganglionic eminence prostate left uterine tube Top expressed in tail of embryo ventricular zone genital tubercle superior frontal gyrus lip superior surface of tongue gallbladder dentate gyrus of hippocampal formation granule cell granulocyte neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component extracellular exosome membrane nucleus cytoplasm nucleoplasm cytosol plasma membrane Biological process cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7916 53761 Ensembl ENSG00000204469 ENSG00000206427 ENSG00000231825 ENSG00000231370 ENSG00000226618 ENSG00000225164 ENSG00000225748 ENSMUSG00000024393 UniProt P48634 Q7TSC1 RefSeq (mRNA) NM_004638 NM_080686 NM_001199044 NM_020027 RefSeq (protein) NP_004629 NP_542417 NP_001185973 NP_064411 Location (UCSC) Chr 6: 31.62 – 31.64 Mb Chr 17: 35.37 – 35.38 Mb PubMed search [3] [4]
Wikidata
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Function

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.^[7]

Interactions

BAT2 has been shown to interact with:

• C1QBP,^[8]
• EIF3S6,^[8]
• HNRNPA1,^[8]
• IFT88,^[8]
• IMMT,^[8] and
• UBAP2L.^[8]