EIF3S6

Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a protein that in humans is encoded by the EIF3E gene.^[5][6][7]

EIF3E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J8B, 3J8C, 5A5T
Identifiers
Aliases	EIF3E, EIF3-P48, EIF3S6, INT6, eIF3-p46, eukaryotic translation initiation factor 3 subunit E
External IDs	OMIM: 602210; MGI: 99257; HomoloGene: 1205; GeneCards: EIF3E; OMA:EIF3E - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q23.1 Start 108,162,787 bp[1] End 108,443,496 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.2|15 16.73 cM Start 43,113,454 bp[2] End 43,146,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii parietal pleura ovary germinal epithelium left ovary ganglionic eminence skin of thigh skin of hip body of pancreas Top expressed in vestibular sensory epithelium primitive streak maxillary prominence mandibular prominence hair follicle medial ganglionic eminence abdominal wall endothelial cell of lymphatic vessel efferent ductule vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity protein N-terminus binding protein binding RNA binding cadherin binding Cellular component cytoplasm eukaryotic translation initiation factor 3 complex PML body membrane nucleoplasm chromatin extracellular exosome nucleus cytosol nuclear body eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex eukaryotic translation initiation factor 3 complex, eIF3e Biological process negative regulation of translational initiation translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis regulation of translational initiation positive regulation of translation positive regulation of mRNA binding formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3646 16341 Ensembl ENSG00000104408 ENSMUSG00000022336 UniProt P60228 P60229 RefSeq (mRNA) NM_001568 NM_008388 RefSeq (protein) NP_001559 NP_032414 Location (UCSC) Chr 8: 108.16 – 108.44 Mb Chr 15: 43.11 – 43.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

EIF3S6 has been shown to interact with:

• BAT2,^[8]
• COPS6^[9]
• CSN3,^[9]
• EIF3A,^[10][11][12] and
• TRIM27.^[13]

See also

• Eukaryotic initiation factor 3 (eIF3)