Bcl-2-like protein 1

Bcl-2-like protein 1 is a protein encoded in humans by the BCL2L1 gene. Through alternative splicing, the gene encodes both of the human proteins Bcl-xL and Bcl-xS.^[5]

BCL2L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 5AGW, 5AGX, 4Z9V, 5FMK, 5FMJ, 5C3G
Identifiers
Aliases	BCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BCLXS, PPP1R52, bcl-xS, BCL2L, BCLX, Bcl-X, bcl-xL, BCL2 like 1
External IDs	OMIM: 600039; MGI: 88139; HomoloGene: 7639; GeneCards: BCL2L1; OMA:BCL2L1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 31,664,452 bp[1] End 31,723,989 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 75.41 cM|2 H1 Start 152,622,588 bp[2] End 152,673,648 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung olfactory zone of nasal mucosa upper lobe of left lung Descending thoracic aorta ascending aorta right coronary artery islet of Langerhans monocyte left coronary artery gallbladder Top expressed in spermatocyte fetal liver hematopoietic progenitor cell blood tibiofemoral joint dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus vestibular membrane of cochlear duct spermatid thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function BH3 domain binding protein binding identical protein binding protein kinase binding protein homodimerization activity protein heterodimerization activity Cellular component cytoplasm integral component of membrane cytosol centrosome nuclear membrane mitochondrial membranes membrane Bcl-2 family protein complex synapse intracellular anatomical structure synaptic vesicle membrane microtubule organizing center cell junction mitochondrial matrix mitochondrion mitochondrial inner membrane cytoskeleton cytoplasmic vesicle nucleus endoplasmic reticulum mitochondrial outer membrane Biological process negative regulation of neuron apoptotic process neuron apoptotic process germ cell development negative regulation of execution phase of apoptosis regulation of apoptotic process response to cytokine male gonad development endocytosis negative regulation of intrinsic apoptotic signaling pathway mitotic cell cycle checkpoint signaling negative regulation of release of cytochrome c from mitochondria response to virus negative regulation of apoptotic process response to cycloheximide in utero embryonic development cellular response to alkaloid negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of mitochondrial membrane potential regulation of mitochondrial membrane permeability apoptotic mitochondrial changes cellular response to gamma radiation spermatogenesis positive regulation of cell population proliferation positive regulation of apoptotic process cellular response to amino acid stimulus ovarian follicle development apoptotic process in bone marrow cell fertilization response to radiation suppression by virus of host apoptotic process cell population proliferation mitochondrion morphogenesis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of autophagy positive regulation of intrinsic apoptotic signaling pathway negative regulation of anoikis hepatocyte apoptotic process release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors growth negative regulation of protein localization to plasma membrane cytokine-mediated signaling pathway regulation of cytokinesis regulation of growth negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 598 12048 Ensembl ENSG00000171552 ENSMUSG00000007659 UniProt Q07817 Q5TE64 Q64373 RefSeq (mRNA) NM_001191 NM_138578 NM_001317919 NM_001317920 NM_001317921 NM_001322239 NM_001322240 NM_001322242 NM_001289716 NM_001289717 NM_001289739 NM_009743 NM_001355053 RefSeq (protein) NP_001182 NP_001304848 NP_001304849 NP_001304850 NP_001309168 NP_001309169 NP_001309171 NP_612815 NP_001276645 NP_001276646 NP_001276668 NP_033873 NP_001341982 Location (UCSC) Chr 20: 31.66 – 31.72 Mb Chr 2: 152.62 – 152.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (voltage-dependent anion channels (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.^[5][6]

Interactions

BCL2-like 1 (gene) has been shown to interact with:

• APAF1,^[7][8]
• BAK1,^{[9][10][11][12][13]}
• BCAP31,^[14]
• BCL2L11,^{[11][15][16][17]}
• BNIP3,^[18]
• BNIPL,^[19][20]
• BAD,^{[10][15][21][22][23][24][25][26][27][28][29]}
• BAX,^{[10][22][30][31]}
• BIK,^{[9][15][31][32]}
• Bcl-2,^[10][33]
• HRK,^[11][34][35]
• IKZF3,^[36]
• Noxa,^[15][37]
• PPP1CA,^[23]
• PSEN2^[38]
• RAD9A,^[9][21]
• RTN1,^[39]
• RTN4,^[39] and
• VDAC1.^{[40][41][42][43]}