BCL2L12

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.^[5][6]

BCL2L12
Identifiers
Aliases	BCL2L12, BCL2 like 12
External IDs	OMIM: 610837; MGI: 1922986; HomoloGene: 12619; GeneCards: BCL2L12; OMA:BCL2L12 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,665,142 bp[1] End 49,673,916 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,640,646 bp[2] End 44,648,136 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gastrocnemius muscle muscle of thigh mucosa of transverse colon granulocyte testicle oocyte right lobe of liver appendix right ovary Top expressed in spermatocyte hand ventricular zone yolk sac maxillary prominence mandibular prominence ascending aorta epiblast foot genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function p53 binding protein binding Cellular component membrane nucleus Biological process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of transcription by RNA polymerase II inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cellular senescence apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83596 75736 Ensembl ENSG00000126453 ENSMUSG00000003190 UniProt Q9HB09 n/a RefSeq (mRNA) NM_001040668 NM_001282516 NM_001282517 NM_001282519 NM_001282520 NM_001282521 NM_138639 NM_001385706 NM_029410 RefSeq (protein) NP_001035758 NP_001269445 NP_001269446 NP_001269448 NP_001269449 NP_001269450 NP_619580 n/a Location (UCSC) Chr 19: 49.67 – 49.67 Mb Chr 7: 44.64 – 44.65 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[5]

Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism.^[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.^[8]