BOP1

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene.^[5][6] It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle.^[7] It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.

BOP1
Identifiers
Aliases	BOP1, block of proliferation 1, BOP1 ribosomal biogenesis factor
External IDs	OMIM: 610596; MGI: 1334460; HomoloGene: 6612; GeneCards: BOP1; OMA:BOP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,262,045 bp[1] End 144,291,438 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D3|15 35.91 cM Start 76,337,189 bp[2] End 76,361,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right hemisphere of cerebellum left lobe of thyroid gland pituitary gland anterior pituitary right uterine tube gastrocnemius muscle right frontal lobe mucosa of transverse colon apex of heart Top expressed in otic placode saccule otic vesicle epiblast somite embryo embryo yolk sac primitive streak mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribonucleoprotein complex binding protein binding RNA binding Cellular component nucleolus nucleus PeBoW complex nucleoplasm preribosome, large subunit precursor ribonucleoprotein complex Biological process ribosomal large subunit biogenesis cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cell population proliferation ribosome biogenesis regulation of cell cycle rRNA processing maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal large subunit assembly regulation of signal transduction by p53 class mediator maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23246 12181 Ensembl ENSG00000261236 ENSG00000285301 ENSMUSG00000022557 UniProt Q14137 P97452 RefSeq (mRNA) NM_015201 NM_013481 RefSeq (protein) NP_056016 NP_038509 Location (UCSC) Chr 8: 144.26 – 144.29 Mb Chr 15: 76.34 – 76.36 Mb PubMed search [3] [4]
Wikidata
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Function

The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans.^[8] Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.^[9]

Nop7p-Erb1p-Ytm1p, found in yeast, is potentially the homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells.^[10] In Giardia, the species specific cytoskeleton protein, beta-giardin, interacts with Bop1.^[7]

Structure

BOP1NT
Identifiers
Symbol	BOP1NT
Pfam	PF08145
InterPro	IPR012953
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

BOP1 contains a conserved N-terminal domain, BOP1NT.