BTF3

Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.^[5][6][7][8]

BTF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LKX, 3MCB
Identifiers
Aliases	BTF3, BETA-NAC, BTF3a, BTF3b, NACB, basic transcription factor 3
External IDs	OMIM: 602542; MGI: 1202875; HomoloGene: 37453; GeneCards: BTF3; OMA:BTF3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 73,498,408 bp[1] End 73,505,667 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 98,446,404 bp[2] End 98,453,514 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon lactiferous duct human penis left ovary embryo vulva ganglionic eminence oral cavity trabecular bone cartilage tissue Top expressed in epiblast lens ventricular zone ganglionic eminence yolk sac embryo embryo thymus blastocyst uterus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm nucleus cytosol nascent polypeptide-associated complex polysomal ribosome Biological process protein transport in utero embryonic development regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 689 218490 Ensembl ENSG00000145741 ENSMUSG00000021660 UniProt P20290 Q64152 RefSeq (mRNA) NM_001207 NM_001037637 NM_001393652 NM_001393653 NM_001170540 NM_145455 RefSeq (protein) NP_001032726 NP_001198 NP_001164011 NP_663430 Location (UCSC) Chr 5: 73.5 – 73.51 Mb Chr 13: 98.45 – 98.45 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.^[8]

Interactions

BTF3 has been shown to interact with CSNK2B.^[9]