CSNK2B

Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.^[5][6] It is a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.^[7]

CSNK2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DS5, 1JWH, 1QF8, 3EED, 4DGL, 4MD7, 4MD8, 4MD9, 4NH1, 2R6M
Identifiers
Aliases	CSNK2B, CK2B, CK2N, CSK2B, G5A, casein kinase 2 beta, Ckb2, Ckb1, POBINDS
External IDs	OMIM: 115441; MGI: 88548; HomoloGene: 55572; GeneCards: CSNK2B; OMA:CSNK2B - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,665,227 bp[1] End 31,670,343 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.59 cM Start 35,335,172 bp[2] End 35,341,029 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis skin of leg skin of abdomen ganglionic eminence left ovary stromal cell of endometrium mucosa of transverse colon right ovary canal of the cervix Top expressed in spermatid seminiferous tubule spermatocyte lip ventricular zone embryo esophagus morula muscle of thigh somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding transcription factor binding chromatin binding metal ion binding protein binding protein kinase regulator activity identical protein binding signaling receptor binding ribonucleoprotein complex binding protein serine/threonine kinase activity Cellular component cytosol PcG protein complex extracellular exosome nucleoplasm chromatin extracellular region nucleus cytoplasm plasma membrane cilium nuclear matrix secretory granule lumen cell projection ficolin-1-rich granule lumen protein kinase CK2 complex Biological process regulation of DNA binding negative regulation of blood vessel endothelial cell migration endothelial tube morphogenesis positive regulation of pathway-restricted SMAD protein phosphorylation Wnt signaling pathway adiponectin-activated signaling pathway positive regulation of activin receptor signaling pathway signal transduction negative regulation of cell population proliferation protein folding regulation of signal transduction by p53 class mediator regulation of protein kinase activity phosphatidylcholine biosynthetic process response to testosterone neutrophil degranulation liver regeneration macroautophagy peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1460 13001 Ensembl ENSG00000228875 ENSG00000204435 ENSG00000232960 ENSG00000206406 ENSG00000224774 ENSG00000230700 ENSG00000224398 ENSMUSG00000024387 UniProt P67870 P67871 RefSeq (mRNA) NM_001320 NM_001282385 NM_009975 NM_001303445 NM_001303446 NM_001303476 RefSeq (protein) NP_001269314 NP_001311 NP_001290374 NP_001290375 NP_001290405 NP_034105 Location (UCSC) Chr 6: 31.67 – 31.67 Mb Chr 17: 35.34 – 35.34 Mb PubMed search [3] [4]
Wikidata
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Casein kinase II regulatory subunit
structure of ck2 beta subunit crystallized in the presence of a p21waf1 peptide
Identifiers
Symbol	CK_II_beta
Pfam	PF01214
InterPro	IPR000704
PROSITE	PDOC00845
SCOP2	1qf8 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Casein kinase, a ubiquitous, well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Serine or Threonine in acidic stretches of amino acids. The enzyme is a tetramer of 2 alpha- and 2 beta-subunits.^[8][9] However, some species (e.g., mammals) possess 2 related forms of the alpha-subunit (alpha and alpha'), while others (e.g., fungi) possess 2 related beta-subunits (beta and beta').^[10] The alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif.^[10] The beta subunit is a highly conserved protein of about 25kDa that contains, in its central section, a cysteine-rich motif, CX(n)C, that could be involved in binding a metal such as zinc.^[11] The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase.^[10]

Interactions

CSNK2B has been shown to interact with CD163,^[12] CSNK2A2,^{[13][14][15][16]} Casein kinase 2, alpha 1,^{[14][15][16][17][18]} FGF1,^[19] TRIB3,^[20] CDC34,^[21] Ribosomal protein L5,^{[13][17][22][23]} BTF3,^[24] BRCA1,^[25] RNF7,^[17] P70-S6 Kinase 1^[26] and APC.^[27]