CSNK2B
Protein-coding gene in humans From Wikipedia, the free encyclopedia
Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.[5][6] It is a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.[7]
| Casein kinase II regulatory subunit | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of ck2 beta subunit crystallized in the presence of a p21waf1 peptide | |||||||||
| Identifiers | |||||||||
| Symbol | CK_II_beta | ||||||||
| Pfam | PF01214 | ||||||||
| InterPro | IPR000704 | ||||||||
| PROSITE | PDOC00845 | ||||||||
| SCOP2 | 1qf8 / SCOPe / SUPFAM | ||||||||
| |||||||||
Casein kinase, a ubiquitous, well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Serine or Threonine in acidic stretches of amino acids. The enzyme is a tetramer of 2 alpha- and 2 beta-subunits.[8][9] However, some species (e.g., mammals) possess 2 related forms of the alpha-subunit (alpha and alpha'), while others (e.g., fungi) possess 2 related beta-subunits (beta and beta').[10] The alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif.[10] The beta subunit is a highly conserved protein of about 25kDa that contains, in its central section, a cysteine-rich motif, CX(n)C, that could be involved in binding a metal such as zinc.[11] The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase.[10]
Interactions
CSNK2B has been shown to interact with CD163,[12] CSNK2A2,[13][14][15][16] Casein kinase 2, alpha 1,[14][15][16][17][18] FGF1,[19] TRIB3,[20] CDC34,[21] Ribosomal protein L5,[13][17][22][23] BTF3,[24] BRCA1,[25] RNF7,[17] P70-S6 Kinase 1[26] and APC.[27]
References
External links
Further reading
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