C5a receptor

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.^[5] C5a receptor 1 modulates inflammatory responses, obesity, development and cancers.^[6][7][8] From a signaling transduction perspective, C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a,^[9] coupling of Gαi proteins,^[10] ERK1/2 phosphorylation, ^[11] calcium mobilization and Rho activation^[12] leading to downstream functions, such as secretion of cytokines, chemotaxis, and phagocytosis.

C5a receptor structure and its residues possessing role in ligand binding or signaling.

C5AR1
Identifiers
Aliases	C5AR1, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor, complement C5a receptor 1
External IDs	OMIM: 113995; MGI: 88232; HomoloGene: 20413; GeneCards: C5AR1; OMA:C5AR1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 47,290,023 bp[1] End 47,322,066 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A2|7 8.77 cM Start 15,980,668 bp[2] End 15,993,465 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte bone marrow granulocyte bone marrow cells pituitary gland right lung anterior pituitary periodontal fiber upper lobe of left lung Top expressed in granulocyte aortic valve stroma of bone marrow ascending aorta blood tibiofemoral joint lumbar spinal ganglion ankle choroid plexus of fourth ventricle right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function complement component C5a binding signal transducer activity complement receptor activity complement component C5a receptor activity G protein-coupled receptor activity Cellular component integral component of membrane membrane plasma membrane apical part of cell integral component of plasma membrane cell surface basolateral plasma membrane cytoplasmic vesicle secretory granule membrane Biological process negative regulation of neuron apoptotic process positive regulation of epithelial cell proliferation mRNA transcription by RNA polymerase II activation of phospholipase C activity neutrophil chemotaxis positive regulation of angiogenesis chemotaxis cellular defense response response to lipopolysaccharide animal organ regeneration immune response response to peptidoglycan positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis complement receptor mediated signaling pathway sensory perception of chemical stimulus positive regulation of vascular endothelial growth factor production cell proliferation in hindbrain positive regulation of macrophage chemotaxis signal transduction defense response to Gram-positive bacterium apoptotic process regulation of complement activation inflammatory response phospholipase C-activating G protein-coupled receptor signaling pathway neutrophil degranulation leukocyte migration cell chemotaxis positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway complement component C5a signaling pathway cognition regulation of astrocyte activation presynapse organization regulation of amyloid-beta clearance regulation of tau-protein kinase activity regulation of microglial cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 728 12273 Ensembl ENSG00000197405 ENSMUSG00000049130 UniProt P21730 P30993 RefSeq (mRNA) NM_001736 NM_001173550 NM_007577 RefSeq (protein) NP_001727 NP_001167021 NP_031603 Location (UCSC) Chr 19: 47.29 – 47.32 Mb Chr 7: 15.98 – 15.99 Mb PubMed search [3] [4]
Wikidata
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Cells

The C5a receptor 1 is expressed on:^[13]

• Granulocytes
• Macrophages
• Monocytes
• Dendritic cells
• Hepatoma-derived cell line HepG2
• Astrocytes
• Microglia

Agonist and antagonists

Potent and selective agonist and antagonists for C5a receptor 1 have been developed.^{[14][15][16][17][18][19]}

See also

• Complement component 5a for binding mechanism