CABIN1

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.^[5][6][7]

CABIN1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1N6J
Identifiers
Aliases	CABIN1, CAIN, PPP3IN, KB-318B8.7, calcineurin binding protein 1
External IDs	OMIM: 604251; MGI: 1298375; HomoloGene: 49307; GeneCards: CABIN1; OMA:CABIN1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23 Start 24,011,192 bp[1] End 24,178,628 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 38.56 cM Start 75,481,946 bp[2] End 75,600,175 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum paraflocculus of cerebellum granulocyte right uterine tube right lobe of thyroid gland right coronary artery apex of heart left lobe of thyroid gland popliteal artery tibial arteries Top expressed in zygote granulocyte secondary oocyte primary visual cortex ventricular zone superior frontal gyrus neural layer of retina yolk sac tail of embryo lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity nucleosome binding Cellular component aggresome nucleus nucleoplasm cytosol Biological process cell surface receptor signaling pathway negative regulation of phosphoprotein phosphatase activity chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23523 104248 Ensembl ENSG00000099991 ENSG00000281670 ENSMUSG00000020196 UniProt Q9Y6J0 n/a RefSeq (mRNA) NM_001199281 NM_001201429 NM_012295 NM_172549 RefSeq (protein) NP_001186210 NP_001188358 NP_036427 n/a Location (UCSC) Chr 22: 24.01 – 24.18 Mb Chr 10: 75.48 – 75.6 Mb PubMed search [3] [4]
Wikidata
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Function

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.^[7]

Interactions

CABIN1 has been shown to interact with:

• Amphiphysin,^[8]
• MEF2B,^[9][10]
• MEF2D,^[10][11] and
• SIN3A.^[11]