MEF2D

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.^[5][6]

MEF2D
Identifiers
Aliases	MEF2D, myocyte enhancer factor 2D
External IDs	OMIM: 600663; MGI: 99533; HomoloGene: 4327; GeneCards: MEF2D; OMA:MEF2D - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,463,727 bp[1] End 156,500,779 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.78 cM Start 88,049,679 bp[2] End 88,079,393 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle popliteal artery tibial arteries saphenous vein apex of heart sural nerve gastric mucosa canal of the cervix right coronary artery Top expressed in Ileal epithelium neural layer of retina perirhinal cortex entorhinal cortex CA3 field muscle of thigh dentate gyrus of hippocampal formation granule cell superior frontal gyrus plantaris muscle primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity protein homodimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific histone deacetylase binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein heterodimerization activity enzyme binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm intracellular membrane-bounded organelle nucleoplasm nucleus Biological process cell differentiation regulation of transcription, DNA-templated chondrocyte differentiation adult heart development muscle organ development endochondral ossification transcription by RNA polymerase II transcription, DNA-templated nervous system development multicellular organism development positive regulation of transcription, DNA-templated osteoblast differentiation skeletal muscle cell differentiation positive regulation of transcription by RNA polymerase II apoptotic process positive regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4209 17261 Ensembl ENSG00000116604 ENSMUSG00000001419 UniProt Q14814 Q63943 RefSeq (mRNA) NM_001271629 NM_005920 NM_133665 NM_001310587 NM_001310593 RefSeq (protein) NP_001258558 NP_005911 NP_001297516 NP_001297522 NP_598426 Location (UCSC) Chr 1: 156.46 – 156.5 Mb Chr 3: 88.05 – 88.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MEF2D has been shown to interact with:

• CABIN1,^[7][8]
• EP300,^[9][7]
• MAPK7,^[10]
• Myocyte-specific enhancer factor 2A,^[11]
• NFATC2^[12]
• Sp1 transcription factor,^[13] and
• YWHAQ.^[14]

See also

• Mef2