CARD10

Caspase recruitment domain-containing protein 10 is a protein in the CARD-CC protein family that in humans is encoded by the CARD10 gene.^[5][6][7]

CARD10
Identifiers
Aliases	CARD10, BIMP1, CARMA3, caspase recruitment domain family member 10, IMD89
External IDs	OMIM: 607209; MGI: 2146012; HomoloGene: 8728; GeneCards: CARD10; OMA:CARD10 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,490,362 bp[1] End 37,519,542 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,659,338 bp[2] End 78,687,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland jejunal mucosa pancreatic ductal cell sural nerve duodenum glomerulus apex of heart metanephric glomerulus mucosa of transverse colon mucosa of ileum Top expressed in dorsomedial hypothalamic nucleus granulocyte ventral tegmental area motor neuron vestibular membrane of cochlear duct pontine nuclei sciatic nerve renal corpuscle human kidney utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor complex adaptor activity protein binding CARD domain binding Cellular component cytoplasm CBM complex Biological process regulation of apoptotic process activation of NF-kappaB-inducing kinase activity negative regulation of cell migration involved in sprouting angiogenesis positive regulation of protein localization to nucleus protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29775 105844 Ensembl ENSG00000100065 ENSMUSG00000033170 UniProt Q9BWT7 P58660 RefSeq (mRNA) NM_014550 NM_130859 RefSeq (protein) NP_055365 NP_570929 Location (UCSC) Chr 22: 37.49 – 37.52 Mb Chr 15: 78.66 – 78.69 Mb PubMed search [3] [4]
Wikidata
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Function

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM]^[7]

Interactions

CARD10 has been shown to interact with BCL10.^[8]