BCL10

B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.^[5][6] Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma.

BCL10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MB9
Identifiers
Aliases	BCL10, CARMEN, CIPER, CLAP, c-E10, mE10, IMD37, B-cell CLL/lymphoma 10, B cell CLL/lymphoma 10, immune signaling adaptor, BCL10 immune signaling adaptor
External IDs	OMIM: 603517; MGI: 1337994; HomoloGene: 2912; GeneCards: BCL10; OMA:BCL10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 85,265,776 bp[1] End 85,276,632 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 145,628,559 bp[2] End 145,640,111 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon oocyte gingival epithelium secondary oocyte epithelium of nasopharynx palpebral conjunctiva germinal epithelium amniotic fluid tibia jejunal mucosa Top expressed in saccule otic placode granulocyte Paneth cell otic vesicle stroma of bone marrow cumulus cell Ileal epithelium blood renal corpuscle More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity transcription factor binding protein kinase B binding NF-kappaB binding protease binding protein self-association kinase binding protein C-terminus binding protein binding kinase activator activity enzyme binding protein kinase binding ubiquitin protein ligase binding identical protein binding CARD domain binding Cellular component cytoplasm cytosol membrane T cell receptor complex lipopolysaccharide receptor complex immunological synapse perinuclear region of cytoplasm membrane raft cytoplasmic microtubule lysosome nucleus CBM complex protein-containing complex Biological process apoptotic process T cell apoptotic process regulation of apoptotic process adaptive immune response B cell apoptotic process regulation of T cell receptor signaling pathway immune system process cell death stimulatory C-type lectin receptor signaling pathway negative regulation of mature B cell apoptotic process toll-like receptor signaling pathway positive regulation of transcription, DNA-templated Fc-epsilon receptor signaling pathway cellular defense response positive regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to mechanical stimulus neural tube closure response to fungus positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity immunoglobulin mediated immune response protein complex oligomerization positive regulation of mast cell cytokine production response to food positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of extrinsic apoptotic signaling pathway positive regulation of phosphorylation response to molecule of bacterial origin I-kappaB kinase/NF-kappaB signaling positive regulation of protein ubiquitination T cell receptor signaling pathway protein homooligomerization innate immune response protein ubiquitination positive regulation of apoptotic process protein heterooligomerization lipopolysaccharide-mediated signaling pathway positive regulation of kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8915 12042 Ensembl ENSG00000142867 ENSMUSG00000028191 UniProt O95999 Q9Z0H7 RefSeq (mRNA) NM_003921 NM_001320715 NM_009740 RefSeq (protein) NP_001307644 NP_003912 NP_001307644.1 NP_033870 Location (UCSC) Chr 1: 85.27 – 85.28 Mb Chr 3: 145.63 – 145.64 Mb PubMed search [3] [4]
Wikidata
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Function

BCL10 was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to activate NF-κB. This protein is reported to interact with other CARD and coiled coil domain containing proteins including CARD9, -10, -11 and -14, which are thought to function as upstream regulators in NF-κB signaling. This protein is found to form a complex with the paracaspase MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and BCL10 thought to synergize in the activation of NF-κB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.^[6] BCL10 is evolutionary conserved since cnidaria and has been shown to be functionally conserved all the way back to zebrafish.^[7][8] Notably, just like the upstream CARD-CC family, BCL10 is absent in insects and nematodes, and the correlated phylogenetic distribution of BCL10 and CARD-CC proteins indicate a conserved complex.

Interactions

BCL10 has been shown to interact with these proteins:

• CARD10,^[9]
• CARD11,^[10]
• CARD14,^[10]
• CARD9^[11]
• CRADD,^[12]
• IKBKG,^[13]
• MALT1,^[14] and
• TRAF2.^[15]