CBX1

Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.^[5][6]

CBX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q6S, 2FMM, 3F2U
Identifiers
Aliases	CBX1, CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta, chromobox 1
External IDs	OMIM: 604511; MGI: 105369; HomoloGene: 89116; GeneCards: CBX1; OMA:CBX1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,070,052 bp[1] End 48,101,478 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 60.11 cM Start 96,679,953 bp[2] End 96,699,466 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone secondary oocyte tendon of biceps brachii internal globus pallidus C1 segment endothelial cell optic nerve amniotic fluid amygdala Top expressed in otic placode saccule Gonadal ridge genital tubercle mandibular prominence tail of embryo abdominal wall maxillary prominence otic vesicle vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone methyltransferase binding enzyme binding chromatin binding protein binding protein homodimerization activity identical protein binding Cellular component chromocenter pericentric heterochromatin chromatin spindle chromosome, centromeric region male pronucleus female pronucleus nucleoplasm nucleus site of DNA damage Biological process negative regulation of transcription, DNA-templated cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10951 12412 Ensembl ENSG00000108468 ENSMUSG00000018666 UniProt P83916 P83917 RefSeq (mRNA) NM_006807 NM_001127228 NM_007622 NM_001362560 NM_001362561 NM_001362563 NM_001362564 RefSeq (protein) NP_001120700 NP_006798 NP_031648 NP_001349489 NP_001349490 NP_001349492 NP_001349493 Location (UCSC) Chr 17: 48.07 – 48.1 Mb Chr 11: 96.68 – 96.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein is localized at heterochromatin sites, where it mediates gene silencing.^[6]

Interactions

CBX1 has been shown to interact with:

• C11orf30,^[7]
• CBX3^[8] and
• CBX5,^[8] and
• SUV39H1.^[9]

See also

• Heterochromatin protein 1