CBX3

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.^[5][6]

CBX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TZD, 2L11, 3DM1, 3KUP
Identifiers
Aliases	CBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
External IDs	OMIM: 604477; MGI: 108515; HomoloGene: 40583; GeneCards: CBX3; OMA:CBX3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 26,201,162 bp[1] End 26,213,607 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 24.89 cM Start 51,447,340 bp[2] End 51,460,684 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell ganglionic eminence visceral pleura ventricular zone parietal pleura germinal epithelium tibia epithelium of nasopharynx trabecular bone endometrium Top expressed in ventricular zone genital tubercle embryo embryo tail of embryo morula dentate gyrus of hippocampal formation granule cell blastocyst yolk sac neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding histone methyltransferase binding protein binding identical protein binding enzyme binding Cellular component nuclear envelope spindle nuclear inner membrane chromatin chromosome, centromeric region nucleus condensed chromosome, centromeric region nucleoplasm site of DNA damage senescence-associated heterochromatin focus Biological process chromatin remodeling regulation of transcription, DNA-templated rhythmic process transcription, DNA-templated negative regulation of transcription, DNA-templated negative regulation of G0 to G1 transition chromatin organization cellular response to DNA damage stimulus cellular response to dexamethasone stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11335 12417 Ensembl ENSG00000122565 ENSMUSG00000029836 UniProt Q13185 P23198 RefSeq (mRNA) NM_007276 NM_016587 NM_001037798 NM_007624 NM_001355002 RefSeq (protein) NP_009207 NP_057671 n/a Location (UCSC) Chr 7: 26.2 – 26.21 Mb Chr 6: 51.45 – 51.46 Mb PubMed search [3] [4]
Wikidata
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At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.^[6]

Interactions

CBX3 has been shown to interact with PIM1,^[7] Ki-67,^[8] Lamin B receptor,^[9] CBX5^[10] and CBX1.^[10]

See also

• Heterochromatin protein 1