CCL22

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.^[4][5][6]

CCL22
Identifiers
Aliases	CCL22, A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1, C-C motif chemokine ligand 22
External IDs	OMIM: 602957; MGI: 1306779; HomoloGene: 7529; GeneCards: CCL22; OMA:CCL22 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 57,358,783 bp[1] End 57,366,189 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix mucosa of urinary bladder lymph node rectum pharynx palpebral conjunctiva vulva tonsil epithelium of colon skin of abdomen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity CCR chemokine receptor binding chemokine activity Cellular component extracellular region extracellular space Biological process G protein-coupled receptor signaling pathway monocyte chemotaxis chemokine-mediated signaling pathway cell-cell signaling cellular response to tumor necrosis factor response to virus neutrophil chemotaxis chemotaxis positive regulation of GTPase activity immune response cellular response to interleukin-1 positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cell chemotaxis lymphocyte chemotaxis signal transduction inflammatory response antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity cytokine-mediated signaling pathway eosinophil chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6367 20299 Ensembl ENSG00000102962 n/a UniProt O00626 O88430 RefSeq (mRNA) NM_002990 NM_009137 RefSeq (protein) NP_002981 NP_033163 Location (UCSC) Chr 16: 57.36 – 57.37 Mb n/a PubMed search [2] [3]
Wikidata
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The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4.^[7] The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.^[8][9]