CCR4

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene.^[5][6][7] CCR4 has also been designated CD194 (cluster of differentiation 194).

CCR4
Identifiers
Aliases	CCR4, CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C motif chemokine receptor 4
External IDs	OMIM: 604836; MGI: 107824; HomoloGene: 21135; GeneCards: CCR4; OMA:CCR4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.3 Start 32,951,644 bp[1] End 32,956,349 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F3|9 64.49 cM Start 114,319,384 bp[2] End 114,333,984 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle appendix lymph node granulocyte gallbladder monocyte blood bone marrow cells rectum spleen Top expressed in thymus morula embryo lumbar subsegment of spinal cord yolk sac lip blastocyst meninges spermatid zone of skin More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-C chemokine receptor activity G protein-coupled receptor activity chemokine receptor activity signal transducer activity protein binding chemokine binding C-C chemokine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane external side of plasma membrane membrane soma intracellular anatomical structure Biological process positive regulation of cytosolic calcium ion concentration chemotaxis chemokine-mediated signaling pathway inflammatory response neuron migration homeostasis of number of cells immune response signal transduction tolerance induction response to bacterium response to antibiotic response to radiation positive regulation of positive chemotaxis G protein-coupled receptor signaling pathway calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1233 12773 Ensembl ENSG00000183813 ENSMUSG00000047898 UniProt P51679 P51680 RefSeq (mRNA) NM_005508 NM_009916 RefSeq (protein) NP_005499 NP_034046 Location (UCSC) Chr 3: 32.95 – 32.96 Mb Chr 9: 114.32 – 114.33 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

• CCL2 (MCP-1)
• CCL4 (MIP-1)
• CCL5 (RANTES)
• CCL17 (TARC)^[8]
• CCL22 (Macrophage-derived chemokine)^[9]

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.^[7]

CCR4 is a cell-surface protein and should not be confused with the unrelated carbon catabolite repression-negative on TATA-less (CCR4-Not), a nuclear protein complex that regulates gene expression.

Clinical significance

CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL).^[10]

As a drug target

Mogamulizumab is a humanised monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL.^[10]