Cyclin A1

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.^[5]

CCNA1
Identifiers
Aliases	CCNA1, CT146, Cyclin A1
External IDs	OMIM: 604036; MGI: 108042; HomoloGene: 31203; GeneCards: CCNA1; OMA:CCNA1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q13.3 Start 36,431,520 bp[1] End 36,442,870 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 54,952,890 bp[2] End 54,962,922 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis ventricular zone right uterine tube ganglionic eminence testicle middle temporal gyrus prefrontal cortex nucleus accumbens Top expressed in spermatid spermatocyte seminiferous tubule embryo embryo ventricular zone left lung lobe granulocyte primary visual cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding Cellular component microtubule cytoskeleton cytosol nucleus nucleoplasm cyclin A1-CDK2 complex cyclin-dependent protein kinase holoenzyme complex cytoplasm cyclin A2-CDK2 complex Biological process cell division cell cycle male meiosis I regulation of transcription involved in G1/S transition of mitotic cell cycle spermatogenesis protein deubiquitination regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8900 12427 Ensembl ENSG00000133101 ENSMUSG00000027793 UniProt P78396 Q61456 RefSeq (mRNA) NM_001111045 NM_001111046 NM_001111047 NM_003914 NM_007628 NM_001305221 RefSeq (protein) NP_001104515 NP_001104516 NP_001104517 NP_003905 NP_001292150 NP_031654 Location (UCSC) Chr 13: 36.43 – 36.44 Mb Chr 3: 54.95 – 54.96 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.^[6]

Interactions

Cyclin-A1 interacts with:

• CDC20,^[7]
• Cyclin-dependent kinase 2,^{[5][8][9][10]}
• E2F1,^[11]
• GNB2L1,^[12]
• GPS2,^[12]
• MYBL2,^[9] and
• Retinoblastoma protein.^[11]