CCNDBP1

Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.^[5][6]

CCNDBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AY5
Identifiers
Aliases	CCNDBP1, DIP1, GCIP, HHM, cyclin D1 binding protein 1
External IDs	OMIM: 607089; MGI: 109595; HomoloGene: 7826; GeneCards: CCNDBP1; OMA:CCNDBP1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.2 Start 43,185,118 bp[1] End 43,197,177 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 60.37 cM Start 120,838,884 bp[2] End 120,847,385 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone mucosa of ileum cardiac muscle tissue of right atrium Achilles tendon bone marrow right uterine tube blood myocardium of left ventricle placenta skin of arm Top expressed in blood zygote secondary oocyte primary oocyte neural layer of retina granulocyte fetal liver hematopoietic progenitor cell cerebellar cortex cerebellar vermis lobe of cerebellum More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus cytoplasm nucleoplasm Biological process regulation of cell cycle cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23582 17151 Ensembl ENSG00000166946 ENSMUSG00000023572 UniProt O95273 Q3TVC7 RefSeq (mRNA) NM_012142 NM_037370 NM_010761 NM_001355127 RefSeq (protein) NP_036274 NP_034891 NP_001342056 Location (UCSC) Chr 15: 43.19 – 43.2 Mb Chr 2: 120.84 – 120.85 Mb PubMed search [3] [4]
Wikidata
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This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.^[6]

Interactions

CCNDBP1 has been shown to interact with GRAP2^[7] and Cyclin D1.^[5]