GRAP2

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.^[5][6][7]

GRAP2
Identifiers
Aliases	GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2, GRB2 related adaptor protein 2
External IDs	OMIM: 604518; MGI: 1333842; HomoloGene: 21007; GeneCards: GRAP2; OMA:GRAP2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,901,084 bp[1] End 39,973,721 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 80,456,795 bp[2] End 80,537,055 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood thymus lymph node testicle spleen epithelium of colon appendix bone marrow cells Top expressed in thymus blood spleen yolk sac embryo mesenteric lymph nodes granulocyte genital tubercle tail of embryo seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding Cellular component cytoplasm cytosol endosome nucleus extrinsic component of cytoplasmic side of plasma membrane Biological process Fc-epsilon receptor signaling pathway cell-cell signaling T cell costimulation Ras protein signal transduction T cell receptor signaling pathway positive regulation of signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation peptidyl-tyrosine autophosphorylation regulation of cell population proliferation innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9402 17444 Ensembl ENSG00000100351 ENSMUSG00000042351 UniProt O75791 O89100 RefSeq (mRNA) NM_001291824 NM_001291825 NM_001291826 NM_001291828 NM_004810 NM_001289442 NM_010815 RefSeq (protein) NP_001278753 NP_001278754 NP_001278755 NP_001278757 NP_004801 NP_001276371 NP_034945 Location (UCSC) Chr 22: 39.9 – 39.97 Mb Chr 15: 80.46 – 80.54 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.^[7]

Interactions

GRAP2 has been shown to interact with:

• CCNDBP1,^[8]
• CD28,^[9]
• Linker of activated T cells,^[6][10]
• Lymphocyte cytosolic protein 2^{[6][9][11][10]}
• MAP4K1,^[12] and
• STAMBP.^[6][11]