CCNG1

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.^[5][6][7]

CCNG1
Identifiers
Aliases	CCNG1, cyclin G1, CCNG
External IDs	OMIM: 601578; MGI: 102890; HomoloGene: 2995; GeneCards: CCNG1; OMA:CCNG1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q34 Start 163,437,569 bp[1] End 163,446,151 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A5 Start 40,639,379 bp[2] End 40,646,138 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa biceps brachii corpus epididymis Skeletal muscle tissue of biceps brachii kidney tubule caput epididymis thoracic diaphragm parotid gland germinal epithelium duodenum Top expressed in intercostal muscle vastus lateralis muscle triceps brachii muscle sternocleidomastoid muscle temporal muscle endothelial cell of lymphatic vessel myocardium of ventricle digastric muscle masseter muscle Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding Cellular component nucleus nucleoplasm cyclin-dependent protein kinase holoenzyme complex cytoplasm Biological process cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity regulation of cell cycle cell division mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 900 12450 Ensembl ENSG00000113328 ENSMUSG00000020326 UniProt P51959 P51945 RefSeq (mRNA) NM_004060 NM_199246 NM_009831 RefSeq (protein) NP_004051 NP_954854 NP_001350944 NP_001350947 NP_001350948 NP_001350949 NP_001350950 NP_001350951 NP_001350952 NP_033961 Location (UCSC) Chr 5: 163.44 – 163.45 Mb Chr 11: 40.64 – 40.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.^[7]

Interactions

CCNG1 has been shown to interact with:

• Mdm2,^[8]
• P16,^[8]
• P53,^[8] and
• PPP2R4.^[9]