PPP2R4

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.^[5][6]

PTPA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G62, 2HV6, 2HV7, 2IXM, 4LAC, 4NY3
Identifiers
Aliases	PTPA, PP2A, PR53, PPP2R4, protein phosphatase 2 regulatory subunit 4, protein phosphatase 2 phosphatase activator
External IDs	OMIM: 600756; MGI: 1346006; HomoloGene: 6149; GeneCards: PTPA; OMA:PTPA - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 129,110,950 bp[1] End 129,148,946 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 21.71 cM Start 30,416,039 bp[2] End 30,447,806 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole apex of heart middle frontal gyrus right frontal lobe anterior cingulate cortex right testis left testis paraflocculus of cerebellum Amygdala Top expressed in aortic valve ascending aorta internal carotid artery external carotid artery dentate gyrus of hippocampal formation granule cell Paneth cell perirhinal cortex Rostral migratory stream molar lactiferous gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein tyrosine phosphatase activator activity protein homodimerization activity isomerase activity peptidyl-prolyl cis-trans isomerase activity ATPase activity protein binding protein heterodimerization activity protein phosphatase 2A binding phosphatase activator activity signaling receptor binding ATP binding protein phosphatase regulator activity Cellular component cytoplasm calcium channel complex protein phosphatase type 2A complex nucleoplasm extracellular exosome nucleus Biological process negative regulation of protein dephosphorylation positive regulation of protein dephosphorylation regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity positive regulation of apoptotic process negative regulation of phosphoprotein phosphatase activity protein peptidyl-prolyl isomerization mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5524 110854 Ensembl ENSG00000119383 ENSMUSG00000039515 UniProt Q15257 P58389 RefSeq (mRNA) NM_001193397 NM_001271832 NM_021131 NM_178000 NM_178001 NM_178002 NM_178003 NM_138748 RefSeq (protein) NP_001180326 NP_001258761 NP_066954 NP_821067 NP_821068 NP_821070 NP_620087 NP_001349662 NP_001349663 Location (UCSC) Chr 9: 129.11 – 129.15 Mb Chr 2: 30.42 – 30.45 Mb PubMed search [3] [4]
Wikidata
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Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

Interactions

PPP2R4 has been shown to interact with PPP2R3A,^[7] CCNG1^[8] and Janus kinase 2.^[9]