CCT2 (gene)

T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene.^[5][6]

CCT2
Identifiers
Aliases	CCT2, 99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta, chaperonin containing TCP1 subunit 2
External IDs	OMIM: 605139; MGI: 107186; HomoloGene: 4696; GeneCards: CCT2; OMA:CCT2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 69,585,426 bp[1] End 69,601,570 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 116,886,906 bp[2] End 116,899,719 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm gonad epithelium of nasopharynx right testis left testis embryo ganglionic eminence ventricular zone gingival epithelium bronchial epithelial cell Top expressed in superior cervical ganglion primitive streak maxillary prominence mandibular prominence abdominal wall hand endothelial cell of lymphatic vessel trigeminal ganglion renal corpuscle medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein folding chaperone activity protein binding ATP binding ubiquitin protein ligase binding unfolded protein binding Cellular component cell body myelin sheath zona pellucida receptor complex chaperonin-containing T-complex microtubule extracellular exosome extracellular matrix extracellular region cytoplasm cytosol azurophil granule lumen Biological process chaperone mediated protein folding independent of cofactor chaperone-mediated protein complex assembly positive regulation of protein localization to Cajal body positive regulation of establishment of protein localization to telomere scaRNA localization to Cajal body protein stabilization positive regulation of telomere maintenance via telomerase toxin transport protein folding positive regulation of telomerase activity positive regulation of telomerase RNA localization to Cajal body binding of sperm to zona pellucida neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10576 12461 Ensembl ENSG00000166226 ENSMUSG00000034024 UniProt P78371 P80314 RefSeq (mRNA) NM_006431 NM_001198842 NM_007636 NM_001358767 RefSeq (protein) NP_001185771 NP_006422 NP_031662 NP_001345696 Location (UCSC) Chr 12: 69.59 – 69.6 Mb Chr 10: 116.89 – 116.9 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.^[6]

Interactions

CCT2 (gene) has been shown to interact with PPP4C.^[7][8]