CCT3

T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.^[5][6]

CCT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GML, 1GN1
Identifiers
Aliases	CCT3, CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5, chaperonin containing TCP1 subunit 3
External IDs	OMIM: 600114; MGI: 104708; HomoloGene: 4373; GeneCards: CCT3; OMA:CCT3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,308,968 bp[1] End 156,367,873 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.79 cM Start 88,204,423 bp[2] End 88,229,074 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad embryo islet of Langerhans ventricular zone ganglionic eminence right adrenal gland smooth muscle tissue right testis left testis right adrenal cortex Top expressed in primitive streak otic placode Paneth cell maxillary prominence saccule mandibular prominence otic vesicle condyle somite spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein folding chaperone activity protein binding ATP binding unfolded protein binding RNA binding Cellular component cell body myelin sheath plasma membrane zona pellucida receptor complex chaperonin-containing T-complex microtubule cytoskeleton extracellular exosome cytoplasm cytosol Biological process positive regulation of protein localization to Cajal body pore complex assembly protein stabilization positive regulation of telomere maintenance via telomerase toxin transport protein folding positive regulation of telomerase RNA localization to Cajal body binding of sperm to zona pellucida 'de novo' protein folding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7203 12462 Ensembl ENSG00000163468 ENSMUSG00000001416 UniProt P49368 Q5SZW8 P80318 RefSeq (mRNA) NM_001008800 NM_001008883 NM_005998 NM_009836 RefSeq (protein) NP_001008800 NP_005989 NP_033966 Location (UCSC) Chr 1: 156.31 – 156.37 Mb Chr 3: 88.2 – 88.23 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

CCT3 has been shown to interact with PPP4C.^[7][8]