CCT6A

T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.^[5][6][7]

CCT6A
Identifiers
Aliases	CCT6A, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20, chaperonin containing TCP1 subunit 6A
External IDs	OMIM: 104613; MGI: 107943; HomoloGene: 1336; GeneCards: CCT6A; OMA:CCT6A - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p11.2 Start 56,051,685 bp[1] End 56,063,989 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,864,062 bp[2] End 129,875,212 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence ventricular zone body of pancreas skin of abdomen superior surface of tongue mucosa of transverse colon skin of leg islet of Langerhans stromal cell of endometrium Top expressed in primitive streak superior cervical ganglion mandibular prominence maxillary prominence abdominal wall migratory enteric neural crest cell Gonadal ridge trigeminal ganglion human fetus somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein folding chaperone activity nucleotide binding WD40-repeat domain binding protein binding ATP binding unfolded protein binding RNA binding Cellular component chaperonin-containing T-complex microtubule extracellular exosome extracellular matrix cytoplasm cytosol Biological process positive regulation of establishment of protein localization to telomere protein stabilization positive regulation of telomere maintenance via telomerase protein folding positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body 'de novo' protein folding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 908 12466 Ensembl ENSG00000146731 ENSMUSG00000029447 UniProt P40227 P80317 RefSeq (mRNA) NM_001762 NM_001009186 NM_009838 RefSeq (protein) NP_001009186 NP_001753 NP_033968 Location (UCSC) Chr 7: 56.05 – 56.06 Mb Chr 5: 129.86 – 129.88 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.^[7]

Interactions

CCT6A has been shown to interact with PPP4C.^[8][9]