CCT7

T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.^[5][6]

CCT7
Identifiers
Aliases	CCT7, CCTETA, CCTH, NIP7-1, TCP1ETA, chaperonin containing TCP1 subunit 7
External IDs	OMIM: 605140; MGI: 107184; HomoloGene: 4694; GeneCards: CCT7; OMA:CCT7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.2 Start 73,233,420 bp[1] End 73,253,021 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 85,428,496 bp[2] End 85,445,457 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone islet of Langerhans right testis left testis right adrenal gland right adrenal cortex left adrenal gland muscle of thigh gastrocnemius muscle Top expressed in primitive streak renal corpuscle medullary collecting duct medial ganglionic eminence hair follicle endothelial cell of lymphatic vessel ureter ascending aorta epiblast aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleotide binding identical protein binding ATP binding protein folding chaperone activity unfolded protein binding Cellular component cytoplasm mitochondrion cytosol cell body zona pellucida receptor complex microtubule extracellular exosome chaperonin-containing T-complex Biological process positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body positive regulation of telomere maintenance via telomerase toxin transport positive regulation of establishment of protein localization to telomere protein folding binding of sperm to zona pellucida protein stabilization 'de novo' protein folding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10574 12468 Ensembl ENSG00000135624 ENSMUSG00000030007 UniProt Q99832 P80313 RefSeq (mRNA) NM_001009570 NM_001166284 NM_001166285 NM_006429 NM_007638 RefSeq (protein) NP_001009570 NP_001159756 NP_001159757 NP_006420 NP_031664 Location (UCSC) Chr 2: 73.23 – 73.25 Mb Chr 6: 85.43 – 85.45 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.^[6]

Interactions

CCT7 has been shown to interact with PPP4C.^[7][8]