T-cell surface glycoprotein CD3 epsilon chain

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.^[5][6]

CD3E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A81, 1SY6, 1XIW, 2ROL
Identifiers
Aliases	CD3E, IMD18, T3E, TCRE, CD3e molecule, CD3epsilon, CD3 epsilon subunit of T-cell receptor complex
External IDs	OMIM: 186830; MGI: 88332; HomoloGene: 586; GeneCards: CD3E; OMA:CD3E - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,304,730 bp[1] End 118,316,175 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 44,910,038 bp[2] End 44,920,925 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte appendix lymph node spleen blood epithelium of colon thymus gallbladder rectum mucosa of transverse colon Top expressed in thymus blood morula blastocyst mesenteric lymph nodes spleen pharynx subcutaneous adipose tissue duodenum jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding signal transducer activity protein binding protein heterodimerization activity signaling receptor complex adaptor activity T cell receptor binding protein kinase binding transmembrane signaling receptor activity protein homodimerization activity Cellular component integral component of membrane membrane cell-cell junction alpha-beta T cell receptor complex plasma membrane integral component of plasma membrane T cell receptor complex immunological synapse external side of plasma membrane dendritic spine cell body Biological process regulation of apoptotic process G protein-coupled receptor signaling pathway positive regulation of calcium-mediated signaling negative regulation of smoothened signaling pathway T cell differentiation in thymus response to nutrient transmembrane receptor protein tyrosine kinase signaling pathway immune system process T cell costimulation positive regulation of interferon-gamma production signal complex assembly negative regulation of gene expression positive regulation of interleukin-4 production negative thymic T cell selection cell surface receptor signaling pathway positive regulation of gene expression positive regulation of T cell anergy positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response apoptotic signaling pathway lymphocyte activation T cell receptor signaling pathway T cell activation protein homooligomerization dendrite development cerebellum development adaptive immune response protein-containing complex assembly positive regulation of cell-matrix adhesion T cell differentiation positive regulation of cell-cell adhesion mediated by integrin positive thymic T cell selection Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 916 12501 Ensembl ENSG00000198851 ENSMUSG00000032093 UniProt P07766 P22646 RefSeq (mRNA) NM_000733 NM_007648 RefSeq (protein) NP_000724 NP_031674 Location (UCSC) Chr 11: 118.3 – 118.32 Mb Chr 9: 44.91 – 44.92 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.^[7]

Clinical significance

Defects in this gene cause severe immunodeficiency.^[8][9] This gene has also been linked to a susceptibility to type I diabetes in women.^[10]

Interactions

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,^[11] CD3EAP^[12] and NCK2.^[13]

See also

• CD3 (immunology)
• Cluster of differentiation