CD96

CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene.^[5] CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1).^[6] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation^{[citation needed]}. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.^[7]

CD96
Identifiers
Aliases	CD96, TACTILE, CD96 molecule
External IDs	OMIM: 606037; MGI: 1934368; HomoloGene: 68489; GeneCards: CD96; OMA:CD96 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.13-q13.2 Start 111,292,719 bp[1] End 111,665,750 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 45,856,020 bp[2] End 45,940,614 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node blood spleen appendix epithelium of colon gallbladder rectum mucosa of transverse colon bone marrow cell Top expressed in thymus seminiferous tubule blood mesenteric lymph nodes ganglion of vagus nerve pharynx spleen subcutaneous adipose tissue secondary oocyte jejunum More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10225 84544 Ensembl ENSG00000153283 ENSMUSG00000022657 UniProt P40200 Q8WUE2 Q3U0X8 RefSeq (mRNA) NM_005816 NM_198196 NM_001318889 NM_032465 RefSeq (protein) NP_001305818 NP_005807 NP_937839 NP_001305818.1 NP_115854 Location (UCSC) Chr 3: 111.29 – 111.67 Mb Chr 16: 45.86 – 45.94 Mb PubMed search [3] [4]
Wikidata
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For the isotope of cadmium (Cd-96 or ⁹⁶Cd), see Cadmium-96.

Function

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].