CDC16

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.^[5][6]

CDC16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HYM, 4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	CDC16, ANAPC6, APC6, CUT9, CDC16Hs, cell division cycle 16
External IDs	OMIM: 603461; MGI: 1917207; HomoloGene: 2899; GeneCards: CDC16; OMA:CDC16 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 114,234,887 bp[1] End 114,272,723 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 13,757,676 bp[2] End 13,781,938 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube bronchial epithelial cell body of pancreas left ovary body of uterus canal of the cervix tibial nerve pars reticulata right ovary skin of abdomen Top expressed in calvaria vas deferens fossa efferent ductule dermis condyle primitive streak abdominal wall ureter mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component microtubule organizing center nucleus spindle microtubule anaphase-promoting complex cytoskeleton nucleoplasm cytosol cytoplasm centrosome spindle Biological process protein K11-linked ubiquitination regulation of mitotic nuclear division anaphase-promoting complex-dependent catabolic process cell population proliferation protein ubiquitination cell division cell cycle mitotic cell cycle regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8881 69957 Ensembl ENSG00000130177 ENSMUSG00000038416 UniProt Q13042 Q8R349 RefSeq (mRNA) NM_001078645 NM_003903 NM_001318517 NM_001318518 NM_001330101 NM_001330104 NM_001330105 NM_027276 NM_001357247 RefSeq (protein) NP_001072113 NP_001305446 NP_001305447 NP_001317030 NP_001317033 NP_001317034 NP_003894 NP_081552 NP_001344176 Location (UCSC) Chr 13: 114.23 – 114.27 Mb Chr 8: 13.76 – 13.78 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[6]

Interactions

CDC16 has been shown to interact with CDC27^{[7][8][9][10]} and CDC20.^{[7][9][11][12]}