CDC23

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.^[5]

CDC23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	CDC23, ANAPC8, APC8, CUT23, cell division cycle 23
External IDs	OMIM: 603462; MGI: 1098815; HomoloGene: 3426; GeneCards: CDC23; OMA:CDC23 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,187,650 bp[1] End 138,213,343 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 18.69 cM Start 34,764,004 bp[2] End 34,784,788 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone tibia endothelial cell rectum cerebellar hemisphere right hemisphere of cerebellum ovary islet of Langerhans left ovary Top expressed in genital tubercle tail of embryo ventricular zone mandibular prominence medullary collecting duct superior cervical ganglion maxillary prominence abdominal wall ganglionic eminence renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding Cellular component nucleoplasm cytosol intracellular anatomical structure anaphase-promoting complex Biological process ubiquitin-dependent protein catabolic process regulation of exit from mitosis regulation of mitotic metaphase/anaphase transition cell cycle cell division protein K11-linked ubiquitination metaphase anaphase-promoting complex-dependent catabolic process protein ubiquitination mitotic metaphase plate congression mitotic cell cycle regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8697 52563 Ensembl ENSG00000094880 ENSMUSG00000024370 UniProt Q9UJX2 Q8BGZ4 RefSeq (mRNA) NM_004661 NM_178347 RefSeq (protein) NP_004652 NP_848124 Location (UCSC) Chr 5: 138.19 – 138.21 Mb Chr 18: 34.76 – 34.78 Mb PubMed search [3] [4]
Wikidata
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Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.^[5]

Interactions

CDC23 has been shown to interact with CDC27.^[6][7]