CDC25C

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.^[5]

CDC25C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OJX, 3BZI, 3OP3
Identifiers
Aliases	CDC25C, CDC25, PPP1R60, cell division cycle 25C
External IDs	OMIM: 157680; MGI: 88350; HomoloGene: 1356; GeneCards: CDC25C; OMA:CDC25C - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,285,265 bp[1] End 138,338,355 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 18.71 cM Start 34,866,046 bp[2] End 34,884,586 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone oocyte testicle secondary oocyte left testis ganglionic eminence right testis sperm mucosa of transverse colon Top expressed in membrana granulosa of ovarian follicle ventricular zone condyle genital tubercle fossa tail of embryo spermatid primitive streak epiblast maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding WW domain binding protein tyrosine phosphatase activity hydrolase activity protein kinase binding phosphoprotein phosphatase activity Cellular component cytoplasm cytosol intracellular anatomical structure nucleoplasm perinuclear region of cytoplasm nucleus nuclear speck Biological process regulation of cyclin-dependent protein serine/threonine kinase activity protein dephosphorylation regulation of cell cycle cell division DNA replication G2/M transition of mitotic cell cycle spermatogenesis cell cycle cell population proliferation viral process regulation of mitotic nuclear division peptidyl-tyrosine dephosphorylation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of cell cycle G2/M phase transition positive regulation of G2/M transition of mitotic cell cycle positive regulation of mitotic cell cycle positive regulation of G2/MI transition of meiotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 995 12532 Ensembl ENSG00000158402 ENSMUSG00000044201 UniProt P30307 P48967 RefSeq (mRNA) NM_001287582 NM_001287583 NM_001790 NM_022809 NM_001318098 NM_001364026 NM_001364027 NM_001364028 NM_009860 RefSeq (protein) NP_001274511 NP_001274512 NP_001305027 NP_001781 NP_073720 NP_001350955 NP_001350956 NP_001350957 NP_033990 Location (UCSC) Chr 5: 138.29 – 138.34 Mb Chr 18: 34.87 – 34.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.^[6]

Interactions

CDC25C has been shown to interact with MAPK14,^[7] CHEK1,^[8] PCNA,^[9] PIN1,^[10][11][12] PLK3^[13] and NEDD4.^[12]

See also

• Cdc25