PLK3

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.^[5][6]

PLK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B6L
Identifiers
Aliases	PLK3, CNK, FNK, PRK, PLK-3, polo like kinase 3
External IDs	OMIM: 602913; MGI: 109604; HomoloGene: 20865; GeneCards: PLK3; OMA:PLK3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 44,800,377 bp[1] End 44,805,990 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 116,985,852 bp[2] End 116,991,160 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte gastric mucosa ascending aorta left uterine tube gallbladder upper lobe of left lung skin of abdomen Descending thoracic aorta monocyte secondary oocyte Top expressed in perirhinal cortex entorhinal cortex CA3 field granulocyte lactiferous gland choroid plexus of fourth ventricle lip left lobe of liver decidua esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity p53 binding kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytoplasm centrosome Golgi apparatus microtubule organizing center soma dendrite nucleolus Golgi stack cytoskeleton nucleus nucleoplasm spindle pole Biological process positive regulation of intracellular protein transport regulation of cytokinesis regulation of cell division protein kinase B signaling phosphorylation response to reactive oxygen species mitotic cell cycle checkpoint signaling mitotic G1/S transition checkpoint signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II cellular response to DNA damage stimulus response to osmotic stress protein phosphorylation G2/M transition of mitotic cell cycle cytoplasmic microtubule organization endomitotic cell cycle cell cycle response to radiation Golgi disassembly apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of signal transduction by p53 class mediator positive regulation of chaperone-mediated autophagy G1/S transition of mitotic cell cycle mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1263 12795 Ensembl ENSG00000173846 ENSMUSG00000028680 UniProt Q9H4B4 Q60806 RefSeq (mRNA) NM_004073 NM_013807 NM_001313916 RefSeq (protein) NP_004064 n/a Location (UCSC) Chr 1: 44.8 – 44.81 Mb Chr 4: 116.99 – 116.99 Mb PubMed search [3] [4]
Wikidata
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Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.^[5]

Interactions

PLK3 has been shown to interact with:

• CDC25C,^[7]
• CHEK2,^[8] and
• P53.^[8][9]