CDC34

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1.^[5][6][7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.^[8]

CDC34
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OB4, 3RZ3, 4MDK
Identifiers
Aliases	CDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme
External IDs	OMIM: 116948; MGI: 102657; HomoloGene: 55815; GeneCards: CDC34; OMA:CDC34 - orthologs
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 531,760 bp[1] End 542,092 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 79,518,029 bp[2] End 79,524,232 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis apex of heart ventricular zone right hemisphere of cerebellum muscle layer of sigmoid colon muscle of thigh ganglionic eminence right lobe of liver gastrocnemius muscle Top expressed in quadriceps femoris muscle muscle of thigh muscle tissue skeletal muscle tissue epiblast testicle placenta lip white adipose tissue yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ubiquitin protein ligase activity ubiquitin-protein transferase activity protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding Cellular component nucleus nucleoplasm cytoplasm cytosol nuclear speck Biological process negative regulation of cAMP-mediated signaling cellular response to interferon-beta protein polyubiquitination positive regulation of inclusion body assembly protein K48-linked ubiquitination positive regulation of neuron apoptotic process DNA replication initiation cell cycle response to growth factor proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination G1/S transition of mitotic cell cycle ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 997 216150 Ensembl ENSG00000099804 ENSMUSG00000020307 UniProt P49427 Q8CFI2 RefSeq (mRNA) NM_004359 NM_177613 NM_001359817 NM_001359818 RefSeq (protein) NP_004350 NP_808281 NP_001346746 NP_001346747 Location (UCSC) Chr 19: 0.53 – 0.54 Mb Chr 10: 79.52 – 79.52 Mb PubMed search [3] [4]
Wikidata
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CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle.^[9] Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1^[10] - for ubiquitin-mediated protein degradation.^[11] CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.^[7]

Interactions

CDC34 has been shown to interact with CSNK2B,^[12] BTRC^[13][14] and CDK9.^[15]