CDC45-related protein

CDC45 is a protein that in humans is encoded by the CDC45L gene.^[5][6][7][8]

CDC45
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DGO
Identifiers
Aliases	CDC45, CDC45L, CDC45L2, PORC-PI-1, CDC45-related protein, cell division cycle 45, MGORS7
External IDs	OMIM: 603465; MGI: 1338073; HomoloGene: 2616; GeneCards: CDC45; OMA:CDC45 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 19,479,457 bp[1] End 19,520,612 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 11.63 cM Start 18,599,197 bp[2] End 18,630,737 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right testis left testis gonad ventricular zone ganglionic eminence testicle mucosa of transverse colon rectum Top expressed in zygote tail of embryo secondary oocyte morula embryo granulocyte spermatid primitive streak ventricular zone spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding single-stranded DNA binding protein binding DNA replication origin binding 3'-5' DNA helicase activity Cellular component cytoplasm DNA replication preinitiation complex centrosome nuclear pre-replicative complex replication fork protection complex nucleoplasm nucleus Biological process double-strand break repair via break-induced replication regulation of transcription involved in G1/S transition of mitotic cell cycle pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA replication checkpoint signaling positive regulation of G1/S transition of mitotic cell cycle DNA replication cell cycle mitotic DNA replication preinitiation complex assembly DNA duplex unwinding DNA replication initiation G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8318 12544 Ensembl ENSG00000093009 ENSMUSG00000000028 UniProt O75419 Q9Z1X9 RefSeq (mRNA) NM_001178010 NM_001178011 NM_003504 NM_001369291 NM_001161623 NM_009862 NM_001358206 RefSeq (protein) NP_001171481 NP_001171482 NP_003495 NP_001356220 NP_001155095 NP_033992 NP_001345135 Location (UCSC) Chr 22: 19.48 – 19.52 Mb Chr 16: 18.6 – 18.63 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein plays a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenylation sites of this gene are reported.^[8]

Interactions

CDC45-related protein has been shown to interact with:

• MCM3,^[9]
• MCM6,^[9]
• MCM7,^[9][10]
• ORC1L,^[9] and
• ORC6L.^[9]