MCM3

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.^[5]

MCM3
Identifiers
Aliases	MCM3, HCC5, P1-P1.h, RLFB, minichromosome maintenance complex component 3
External IDs	OMIM: 602693; MGI: 101845; HomoloGene: 1791; GeneCards: MCM3; OMA:MCM3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.2 Start 52,264,009 bp[1] End 52,284,881 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A4 Start 20,873,192 bp[2] End 20,890,536 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo ganglionic eminence mucosa of transverse colon appendix rectum lymph node gonad trabecular bone body of uterus Top expressed in somite epiblast mandibular prominence fetal liver hematopoietic progenitor cell maxillary prominence ventricular zone primitive streak tail of embryo otic placode abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity protein binding hydrolase activity ATP binding DNA replication origin binding single-stranded DNA binding Cellular component cytoplasm centrosome membrane nucleoplasm perinuclear region of cytoplasm alpha DNA polymerase:primase complex MCM complex nucleus nucleolus intracellular membrane-bounded organelle Biological process G1 phase DNA replication DNA replication initiation cell cycle G1/S transition of mitotic cell cycle double-strand break repair via break-induced replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA strand elongation involved in DNA replication mitotic DNA replication initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4172 17215 Ensembl ENSG00000112118 ENSMUSG00000041859 UniProt P25205 Q7Z6P5 P25206 RefSeq (mRNA) NM_002388 NM_001270472 NM_008563 RefSeq (protein) NP_001257401 NP_002379 NP_001353298 NP_001353299 NP_001353300 NP_001353301 NP_001353302 NP_001353303 NP_001353304 NP_032589 Location (UCSC) Chr 6: 52.26 – 52.28 Mb Chr 1: 20.87 – 20.89 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.^[6]

Interactions

MCM3 has been shown to interact with:

• CDC45-related protein,^[7]
• CDC6,^[8][9]
• DBF4,^[7]
• MCM2^[7]
• MCM3AP,^[10][11][12]
• MCM5,^[7][13]
• MCM7,^{[7][8][14][15]}
• ORC4L,^[7] and
• ORC5L.^[7]

See also

• Mini Chromosome Maintenance