CDK5RAP3

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.^[5][6]

CDK5RAP3
Identifiers
Aliases	CDK5RAP3, C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit associated protein 3
External IDs	OMIM: 608202; MGI: 1933126; HomoloGene: 12718; GeneCards: CDK5RAP3; OMA:CDK5RAP3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,967,810 bp[1] End 47,981,781 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 96,798,252 bp[2] End 96,807,322 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland right uterine tube anterior pituitary right lobe of thyroid gland body of pancreas left lobe of thyroid gland spleen right hemisphere of cerebellum left testis right testis Top expressed in lacrimal gland yolk sac molar parotid gland left lobe of liver seminal vesicula spermatocyte spermatid islet of Langerhans primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MDM2/MDM4 family protein binding NF-kappaB binding mitogen-activated protein kinase binding protein binding ubiquitin-like protein ligase binding protein kinase binding cyclin binding Cellular component cytoplasm centrosome membrane microtubule organizing center nucleolus microtubule cytoskeleton endomembrane system nucleus cytosol protein-containing complex Biological process negative regulation of protein phosphorylation regulation of neuron differentiation protein ufmylation positive regulation of signal transduction by p53 class mediator regulation of phosphatase activity endoplasmic reticulum unfolded protein response mitotic G2/M transition checkpoint brain development apoptotic nuclear changes negative regulation of MAP kinase activity positive regulation of ubiquitin-dependent protein catabolic process negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of protein serine/threonine kinase activity cell population proliferation mitotic G2 DNA damage checkpoint signaling negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination positive regulation of transcription by RNA polymerase II positive regulation of protein localization to nucleus regulation of cyclin-dependent protein serine/threonine kinase activity regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80279 80280 Ensembl ENSG00000108465 ENSMUSG00000018669 UniProt Q96JB5 Q99LM2 RefSeq (mRNA) NM_001278197 NM_001278198 NM_001278216 NM_001278217 NM_025197 NM_176095 NM_176096 NM_030248 NM_001308183 NM_001363255 NM_001363256 RefSeq (protein) NP_001265126 NP_001265127 NP_001265145 NP_001265146 NP_788276 NP_001295112 NP_084524 NP_001350184 NP_001350185 Location (UCSC) Chr 17: 47.97 – 47.98 Mb Chr 11: 96.8 – 96.81 Mb PubMed search [3] [4]
Wikidata
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Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.^[6]