CDK5R1

Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.^[5][6]

CDK5R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H4L, 1UNG, 1UNH, 1UNL, 3O0G
Identifiers
Aliases	CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1
External IDs	OMIM: 603460; MGI: 101764; HomoloGene: 31200; GeneCards: CDK5R1; OMA:CDK5R1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 32,486,993 bp[1] End 32,491,253 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 47.94 cM Start 80,367,849 bp[2] End 80,372,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Region I of hippocampus proper Brodmann area 23 ventricular zone superior frontal gyrus orbitofrontal cortex Brodmann area 9 Parietal Lobe postcentral gyrus entorhinal cortex Top expressed in Rostral migratory stream medial dorsal nucleus medial ganglionic eminence olfactory tubercle nucleus accumbens medial geniculate nucleus prefrontal cortex lateral geniculate nucleus lateral septal nucleus subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity calcium ion binding ephrin receptor binding cadherin binding cyclin-dependent protein serine/threonine kinase activator activity kinase activity protein binding protein kinase binding protein serine/threonine kinase activator activity protease binding actin binding ionotropic glutamate receptor binding alpha-tubulin binding beta-tubulin binding actin filament binding protein kinase activator activity Cellular component cytoplasm cytosol membrane postsynaptic density intracellular membrane-bounded organelle growth cone neuromuscular junction dendritic spine axon soma dendrite protein kinase 5 complex perinuclear region of cytoplasm contractile fiber nucleus nucleoplasm plasma membrane microtubule neuron projection presynapse Biological process positive regulation of protein kinase activity regulation of neuron differentiation G protein-coupled acetylcholine receptor signaling pathway regulation of cyclin-dependent protein serine/threonine kinase activity regulation of actin cytoskeleton organization embryo development rhythmic process ephrin receptor signaling pathway neuron cell-cell adhesion regulation of microtubule cytoskeleton organization neuron migration cerebellum development positive regulation of protein serine/threonine kinase activity positive regulation of neuron apoptotic process brain development ionotropic glutamate receptor signaling pathway layer formation in cerebral cortex peptidyl-serine phosphorylation neuron differentiation cell population proliferation peptidyl-threonine phosphorylation negative regulation of transcription, DNA-templated neuron projection development cerebral cortex radially oriented cell migration axonal fasciculation hippocampus development negative regulation of axon extension regulation of dendritic spine morphogenesis regulation of macroautophagy superior olivary nucleus maturation positive regulation of protein targeting to membrane axon guidance regulation of signal transduction by p53 class mediator serine phosphorylation of STAT protein microtubule cytoskeleton organization embryo development ending in birth or egg hatching positive regulation of microtubule polymerization positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of synaptic vesicle cycle activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8851 12569 Ensembl ENSG00000176749 ENSMUSG00000048895 UniProt Q15078 P61809 RefSeq (mRNA) NM_003885 NM_009871 RefSeq (protein) NP_003876 NP_034001 Location (UCSC) Chr 17: 32.49 – 32.49 Mb Chr 11: 80.37 – 80.37 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.^[6]

In melanocytic cells CDK5R1 gene expression may be regulated by MITF.^[7]

Interactions

CDK5R1 has been shown to interact with:

• Actinin, alpha 1^[8]
• Amphiphysin,^[9]
• Beta-catenin,^[10]
• CAMK2A,^[11]
• CDK5RAP2,^[12]
• Cyclin-dependent kinase 5,^[13][14]
• Protein SET,^[15]

See also

• CDK5RAP1
• CDK5RAP2
• CDK5RAP3